P/CAF

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Name
p300/CBP-associated factor
Symbol
P/CAF
P/CAF is an acetyltransferase that was originally characterized as an interacting partner of the transcriptional co-integrators CBP and p300. It has been shown to potentiate signaling by nuclear receptors.

At a Glance

Nomenclature
general control nonderepressed 5 (GCN5); p300/CBP-associated factor (PCAF); p300/CBP-associated factor (P/CAF)

Primary References
Blanco JC, Minucci S, Lu J, Yang XJ, Walker KK, Chen H, Evans RM, Nakatani Y and Ozato K (1998) The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev 12, 1638-51. View Abstract | View PubMed

Yang XJ, Ogryzko VV, Nishikawa J, Howard BH and Nakatani Y (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382, 319-24. View Abstract | View PubMed


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