PELP1

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Name
Proline, glutamic acid, leucine-rich protein 1
Symbol
PELP1

Overview

PELP1 was originally isolated in a screen for Src homology domain 2 (SH2)-interacting factors and was originally shown to function as a coregulator through its ability to coactivate estrogen receptor-α (ERα ) function.

Note: the paper implicating MNAR in the crosstalk of ER with members of the Src family of tyrosine kinases has been retracted. Retraction statement on PubMedCentral.

Expression

PELP1 is expressed in a variety of major physiological systems, including the central nervous system (brain) and the cardiovascular (heart), metabolic (kidney, liver, skeletal muscle), gastrointestinal (colon) and reproductive (testis, ovary, mammary, prostate) systems.

Disease

PELP1 has been shown to overexpressed in endometrial cancer and salivary duct carcinoma.

View PELP1 Diseases section

 


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Proline, glutamic acid, leucine-rich protein 1 (PELP1); Modulator of nongenomic activity of estrogen receptor (MNAR)

Primary References
Wong CW, McNally C, Nickbarg E, Komm BS and Cheskis BJ (2002) Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. Proc Natl Acad Sci U S A 99, 14783-8. View Abstract | View PubMed
Vadlamudi RK, Wang RA, Mazumdar A, Kim Y, Shin J, Sahin A and Kumar R (2001) Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. J Biol Chem 276, 38272-9. View Abstract | View PubMed

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