SKIP

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Name
SKI interacting protein
Symbol
SKIP

 

Overview

SKIP was originally identified as an interacting partner of the product of the v-Ski avian retroviral oncogene. It was subsequently characterized as a nuclear receptor coregulator on the basis of its ability to act as a coactivator for vitamin D receptor (VDR).

Expression

SKIP is expressed in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the pancreas, skeletal muscle, placenta and heart.

PubMed

 


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
SNW domain containing 1 (SNW1); Nuclear coactivator 62 kDa (NCoA-62); SKI interacting protein (SKIIP)

Primary References
Baudino TA, Kraichely DM, Jefcoat SC, Winchester SK, Partridge NC and MacDonald PN (1998) Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription. J Biol Chem 273, 16434-41. View Abstract | View PubMed
Dahl R, Wani B and Hayman MJ (1998) The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42. Oncogene 16, 1579-86. View Abstract | View PubMed

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