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Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Symbol
DNAJA1
DjA1 is a negative modulator for AR transactivation, and loss of DjA1 in mice led to severe defects in spermatogenesis that involve aberrant androgen signaling. Direct involvment of DjA1 in AR or another nuclear receptor-mediated transcription, however, has yet to be demostrated. *** thus ActiveFlag = 0 ***

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
DnaJ (Hsp40) homolog, subfamily A, member 1 (DNAJA1)

Primary References
Terada K, Yomogida K, Imai T, Kiyonari H, Takeda N, Kadomatsu T, Yano M, Aizawa S and Mori M (2005) A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. EMBO J 24, 611-22. View Abstract | View PubMed
Hernández MP, Chadli A and Toft DO (2002) HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. J Biol Chem 277, 11873-81. View Abstract | View PubMed
Chellaiah A, Davis A and Mohanakumar T (1993) Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein. Biochim Biophys Acta 1174, 111-3. View Abstract | View PubMed

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