Overview

RHA is a member of the DEAD family of nuclear ATPases that unwinds double-stranded RNA in a 3' to 5' direction. It was identified as a nuclear receptor coregulator based on its role as a coactivator for activation function 1 (AF-1) of the mineralocorticoid receptor (MR), a steroid member of the nuclear receptor superfamily of transcription factors. Aldosterone-bound MR was shown to recruit complexes containing RHA and another coregulator, CBP, to native MR target gene promoters.

Phenotypes

Targeted deletion (knockout) of RHA in mice results in early lethality arising from defects in early embryonic development, including differentiation of embryonic ectoderm and normal gastrulation.

View RHA Phenotypes section

Coregulator Pages User Guide (updated Oct 2008)

	At a Glance
	Nomenclature RNA Helicase A (RHA); DEAH (Asp-Glu-Ala-His) box polypeptide 9 (DHX9) Primary References Kitagawa H, Yanagisawa J, Fuse H, Ogawa S, Yogiashi Y, Okuno A, Nagasawa H, Nakajima T, Matsumoto T and Kato S (2002) Ligand-selective potentiation of rat mineralocorticoid receptor activation function 1 by a CBP-containing histone acetyltransferase complex. Mol Cell Biol 22, 3698-706. View Abstract \| View PubMed Lee CG and Hurwitz J (1993) Human RNA helicase A is homologous to the maleless protein of Drosophila. J Biol Chem 268, 16822-30. View Abstract \| View PubMed	At a Glance Orthologs Datasets Interactions Transcriptomics and Cistromics Diseases and Phenotypes Molecular Endocrinology Literature

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Overview

Phenotypes

At a Glance

At a Glance

Orthologs

Datasets

Interactions

Transcriptomics and Cistromics

Diseases and Phenotypes

Molecular Endocrinology

Literature