p68

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Name
Probable RNA-dependent helicase p68
Symbol
p68
The DEAD-box RNA helicase p68 (DDX5) coactivates estrogen receptor-α (ERα) through its AF-1 domain. The interaction between p68 and the human ERα is regulated by MAPK-induced phosphorylation of Ser(118) of the receptor.

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Probable RNA-dependent helicase p68 (p68); DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (DDX5)

Primary References
Masuhiro Y, Mezaki Y, Sakari M, Takeyama K, Yoshida T, Inoue K, Yanagisawa J, Hanazawa S, O'malley BW and Kato S (2005) Splicing potentiation by growth factor signals via estrogen receptor phosphorylation. Proc Natl Acad Sci U S A 102, 8126-31. View Abstract | View PubMed
Endoh H, Maruyama K, Masuhiro Y, Kobayashi Y, Goto M, Tai H, Yanagisawa J, Metzger D, Hashimoto S and Kato S (1999) Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. Mol Cell Biol 19, 5363-72. View Abstract | View PubMed

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