DRIP150

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Name
Vitamin D receptor-interacting protein complex component 150
Symbol
DRIP150
The broad-specificity DRIP/TRAP coregulator complex mediates transcriptional activation by members of the nuclear receptor superfamily and other transcription factors. The DRIP150 subunit has been individually characterized as a nuclear receptor coactivator.

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Activator-recruited cofactor 150 kDa component (ARC150); Thyroid hormone receptor-associated protein complex 170 kDa component (TRAP170); Vitamin D receptor-interacting protein complex component 150 (DRIP150); Cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa (CRSP2)

Primary References
Wang Q, Sharma D, Ren Y and Fondell JD (2002) A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J Biol Chem 277, 42852-8. View Abstract | View PubMed
Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W and Tjian R (1999) Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 398, 828-32. View Abstract | View PubMed
Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J and Roeder RG (1999) A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell 3, 97-108. View Abstract | View PubMed
Fondell JD, Ge H and Roeder RG (1996) Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc Natl Acad Sci U S A 93, 8329-33. View Abstract | View PubMed
Lee JW, Choi HS, Gyuris J, Brent R and Moore DD (1995) Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol Endocrinol 9, 243-54. View Abstract | View Mol Endocrinol

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