CBP

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Name
CREB-binding protein
Symbol
CBP
CBP, and the closely related protein p300, are transcriptional cointegrators which mediate the functions of multiple transcription factors, including members of the nuclear receptor superfamily, in a wide variety of developmental and physiological processes.

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
CREB-binding protein (CBP); CREB binding protein (Rubinstein-Taybi syndrome) (CREBBP)

Primary References
Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK and Rosenfeld MG (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85, 403-14. View Abstract | View PubMed
Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR and Goodman RH (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-9. View Abstract | View PubMed

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