CDK7

Browse coregulators
|
 
Name
Cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
Symbol
CDK7
CDK7, a component of the TFIIH transcription complex, was shown to stimulate recombinant RAR α Ser-77 phosphorylation in vivo and to enhance RAR α-mediated transactivation. These findings represented the first example of activation of a transactivator through binding to and phosphorylation by a general transcription factor.

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) (CDK7)

Primary References
Rochette-Egly C, Adam S, Rossignol M, Egly JM and Chambon P (1997) Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell 90, 97-107. View Abstract | View PubMed
Fisher RP and Morgan DO (1994) A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78, 713-24. View Abstract | View PubMed

My NURSA
Username
Password
Remember me
Forgot your password? Get it here.
Need to register? Click here.
Molecule Navigator
Receptors
Coregulators
Ligands
Select a range
1-E    F-L    M-Q    R-Z   
Select a specific molecule
Feedback

Questions? Comments?
Send Feedback Here

 
© 2003 - 2010 NURSA, The Nuclear Receptor Signaling Atlas.