Cyclin E1

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Name
Cyclin E1
Symbol
Cyclin E1
Cyclin E is a regulatory subunit of the cyclin dependent kinase CDK2, driving cell cycle progression from G1 to S phase, and increased expression of cyclin E is a frequent event in human malignancies. Cyclin E has been identified as an AF-1 specific coactivator of androgen receptor (AR) mediated transcription.

Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Cyclin E1 (CCNE1)

Primary References
Yamamoto A, Hashimoto Y, Kohri K, Ogata E, Kato S, Ikeda K and Nakanishi M (2000) Cyclin E as a coactivator of the androgen receptor. J Cell Biol 150, 873-80. View Abstract | View PubMed
Lew DJ, Dulić V and Reed SI (1991) Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 66, 1197-206. View Abstract | View PubMed

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