CAV1

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Name
Caveolin-1, caveolae protein, 22kDa
Symbol
CAV1
Caveolin-1, a principal component of plasma membrane vesicles (caveloae), which acts as a platform protein for many signal transduction pathways, has been shown to be a coactivator of nuclear receptors.

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Caveolin-1, caveolae protein, 22kDa (CAV1)

Primary References
Schlegel A, Wang C, Pestell RG and Lisanti MP (2001) Ligand-independent activation of oestrogen receptor alpha by caveolin-1. Biochem J 359, 203-10. View Abstract | View PubMed
Schlegel A, Wang C, Katzenellenbogen BS, Pestell RG and Lisanti MP (1999) Caveolin-1 potentiates estrogen receptor alpha (ERalpha) signaling. caveolin-1 drives ligand-independent nuclear translocation and activation of ERalpha. J Biol Chem 274, 33551-6. View Abstract | View PubMed
Rothberg KG, Heuser JE, Donzell WC, Ying YS, Glenney JR and Anderson RG (1992) Caveolin, a protein component of caveolae membrane coats. Cell 68, 673-82. View Abstract | View PubMed

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