SF3A1

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Name
Splicing factor 3a, subunit 1, 120kDa
Symbol
SF3A1
Splicing factor SF3A subunit 1 was characterized as a component of the ER-AF1 complex to potentiate human ERα-mediated transactivation as well as RNA splicing through interaction with Ser118 phosphorylated receptor, suggesting that MAPK-mediated cross-talk between growth factor and estrogen-signaling pathways can modulate RNA splicing through the phosphorylation-dependent interaction between ERα and a component of the spliceosome complex.

Coregulator Pages User Guide (updated Oct 2008)

At a Glance Go to
Nomenclature
splicing factor 3a, subunit 1, 120kDa (SF3A1); splicing factor 3a 120kDa (SF3a p120); Spliceosome associated protein 114 (SAP114); pre-RNA processing 21 (PRP21)

Primary References
Brosi R, Hauri HP and Krämer A (1993) Separation of splicing factor SF3 into two components and purification of SF3a activity. J Biol Chem 268, 17640-6. View Abstract | View PubMed

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