pp32

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Name
Phosphoprotein 32 Kda
Symbol
pp32
pp32 was found associated with ERα in MCF7 cells and and to enhance ER-ERE complex formation but to decrease ER-mediated transcription, possibly through pp32 ability to decrease acetylation of ERα and histones. pp32 was also reported to bind to TRβ, PR-B, PPARγ and AR. Howver, pp32 was reported to act as a coactivator for AR-mediated transcription and this activity is modulated by the retinoblastoma protein.

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Phosphoprotein 32 Kda (pp32); acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A)

Primary References
Adegbola O and Pasternack GR (2005) A pp32-retinoblastoma protein complex modulates androgen receptor-mediated transcription and associates with components of the splicing machinery. Biochem Biophys Res Commun 334, 702-8. View Abstract | View PubMed
Loven MA, Davis RE, Curtis CD, Muster N, Yates JR and Nardulli AM (2004) A novel estrogen receptor alpha-associated protein alters receptor-deoxyribonucleic acid interactions and represses receptor-mediated transcription. Mol Endocrinol 18, 2649-59. View Abstract | View Mol Endocrinol
Seo SB, McNamara P, Heo S, Turner A, Lane WS and Chakravarti D (2001) Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell 104, 119-30. View Abstract | View PubMed
Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B, Kratzin HD and Hilschmann N (1994) Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII. Biol Chem Hoppe Seyler 375, 113-26. View Abstract | View PubMed

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