PGC-1β

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Name
PPAR-γ coactivator 1 β
Symbol
PGC-1β

PGC-1β is a protein related to the cold-inducible coactivator PGC-1 α, and has been shown to coactivate several nuclear receptors. Like PGC1-α, it is highly expressed in brown fat and heart and induced in the liver during fasting, indicating a potential role in hepatic gluconeogenesis.


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
PPAR-γ coactivator 1 β (PGC-1β); Peroxisome proliferator-activated receptor γ coactivator (PERC); Peroxisome proliferative activated receptor, γ, coactivator 1, β (PPARGC1B)

Primary References
Kressler D, Schreiber SN, Knutti D and Kralli A (2002) The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J Biol Chem 277, 13918-25. View Abstract | View PubMed
Lin J, Puigserver P, Donovan J, Tarr P and Spiegelman BM (2002) Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem 277, 1645-8. View Abstract | View PubMed

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