Alien

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Name
Alien
Symbol
Alien

Overview

Alien is a conserved transcriptional corepressor which mediates repression by several members of the nuclear receptor superfamily of transcription factors. It was first characterized as a nuclear receptor coregulator through its role as a corepressor for thyroid receptor (TR), ecdysone receptor (EcR) and svp.

Expression

Alien is expressed at low to moderate levels in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the testis.

View full NURSA Alien expression dataset

Phenotypes

Targeted disruption (knockout) of the Alien gene causes deficient cell proliferation, accumulation of p53 and cyclin E and early embryonic death

View Alien Phenotypes section


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
alien CG9556-PA, alien CG9556-PB (Alien); Thyroid receptor interacting protein 15 (TRIP15)

Primary References
Moehren U, Dressel U, Reeb CA, Väisänen S, Dunlop TW, Carlberg C and Baniahmad A (2004) The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien. Nucleic Acids Res 32, 2995-3004. View Abstract | View PubMed
Altincicek B, Tenbaum SP, Dressel U, Thormeyer D, Renkawitz R and Baniahmad A (2000) Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. J Biol Chem 275, 7662-7. View Abstract | View PubMed
Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R and Baniahmad A (1999) Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol Cell Biol 19, 3383-94. View Abstract | View PubMed
Lee JW, Choi HS, Gyuris J, Brent R and Moore DD (1995) Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol Endocrinol 9, 243-54. View Abstract | View Mol Endocrinol

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