P-TEFb

Browse coregulators
|
 
Name
Positive elongation factor b
Symbol
P-TEFb
PITALRE/CDK9, a CDC2-related protein kinase which targets RNA polymerase II, is a subunit of the general elongation factor P-TEFb. It has been shown to interact with the androgen receptor (AR), and a kinase-defective form of PITALRE inhibits AR-mediated transcription.

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance Go to
Nomenclature
Pro-Ile-Thr-Ala-Leu-Arg-Glu (PITALRE); Positive elongation factor b (P-TEFb); Cyclin-dependent kinase 9 (CDK9)

Primary References
Lee DK, Duan HO and Chang C (2001) Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation. J Biol Chem 276, 9978-84. View Abstract | View PubMed
Graña X, De Luca A, Sang N, Fu Y, Claudio PP, Rosenblatt J, Morgan DO and Giordano A (1994) PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc Natl Acad Sci U S A 91, 3834-8. View Abstract | View PubMed

My NURSA
Username
Password
Remember me
Forgot your password? Get it here.
Need to register? Click here.
Molecule Navigator
Receptors
Coregulators
Ligands
Select a range
1-E    F-L    M-Q    R-Z   
Select a specific molecule
Feedback

Questions? Comments?
Send Feedback Here

 
© 2003 - 2010 NURSA, The Nuclear Receptor Signaling Atlas.