TRAP25

Browse coregulators
|
 
Name
Thyroid hormone receptor-associated protein (25 kDa)
Symbol
TRAP25

Overview

TRAP25 is a subunit of the human TRAP/Mediator complex, which is phylogenetically related to the yeast SRB/Mediator coregulator complex, and facilitates activation through a wide variety of transcriptional activators, including members of the nuclear receptor superfamiy.

Expression

TRAP25 is expressed in a variety of physiological systems, including the central nervous system (brain), endocrine (pancreas), metabolic (liver, skeletal muscle, kidney), cardiovascular (heart) and respiratory (lung) systems.

PubMed


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Thyroid hormone receptor-associated protein (25 kDa) (THRAP6); Thyroid hormone receptor-associated protein (25 kDa) (TRAP25)

Primary References
Baek HJ, Malik S, Qin J and Roeder RG (2002) Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol 22, 2842-52. View Abstract | View PubMed
Fondell JD, Ge H and Roeder RG (1996) Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc Natl Acad Sci U S A 93, 8329-33. View Abstract | View PubMed

My NURSA
Username
Password
Remember me
Forgot your password? Get it here.
Need to register? Click here.
Molecule Navigator
Receptors
Coregulators
Ligands
Select a range
1-E    F-L    M-Q    R-Z   
Select a specific molecule
Feedback

Questions? Comments?
Send Feedback Here

 
© 2003 - 2010 NURSA, The Nuclear Receptor Signaling Atlas.