TBLR1

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Name
Nuclear receptor co-repressor/HDAC3 complex subunit TBLR1
Symbol
TBLR1

Overview

TBLR1 and its related protein TBL1 are WD-40 repeat proteins that have been identified as members of a SMRT complex and were originally shown to be corepressors of unliganded thyroid receptor (TR).

 


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Nuclear receptor co-repressor/HDAC3 complex subunit TBLR1 (TBLR1); transducin (β)-like 1X-linked (TBL1X)

Primary References
Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J and Wong J (2003) Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J 22, 1336-46. View Abstract | View PubMed
Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA and Shiekhattar R (2000) A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev 14, 1048-57. View Abstract | View PubMed
Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A and Borsani G (1999) X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. Am J Hum Genet 64, 1604-16. View Abstract | View PubMed

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