EDD

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Name
E3 isolated by differential display
Symbol
EDD

Overview

EDD, originally identified as a HECT domain ubiquitin-protein ligase, has been characterized as a coactivator for the progesterone receptor (PR), in addition to regulating other signaling pathways such as those mediated by Hedgehog, and the BMP family member Decapentaplegic.

Expression

EDD is expressed in most major physiological systems, including the central nervous system (brain), and the endocrine (pancreas), metabolic (skeletal muscle), gastrointestinal (small intestine), immune (thymus), reproductive (ovary, testis, prostate, placenta) and cardiovascular (heart, leukocytes) systems.

PubMed

Phenotypes

Targeted deletion (knockout) of EDD in mice suggests a crucial role in yolk sac vascularization and chorioallantoic fusion.

View EDD Phenotypes section


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
E3 isolated by differential display (EDD); Progestin-induced protein DD5 (DD5)

Primary References
Henderson MJ, Russell AJ, Hird S, Muñoz M, Clancy JL, Lehrbach GM, Calanni ST, Jans DA, Sutherland RL and Watts CK (2002) EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J Biol Chem 277, 26468-78. View Abstract | View PubMed
Callaghan MJ, Russell AJ, Woollatt E, Sutherland GR, Sutherland RL and Watts CK (1998) Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs. Oncogene 17, 3479-91. View Abstract | View PubMed

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