GT198

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Name
Nuclear Receptor Coactivator GT198
Symbol
GT198

Overview

Originally characterized as a transcript mapping to the human breast cancer susceptibility locus 17q12-q21, GT198 was subsequently shown to be a testis-enriched nuclear receptor (NR) coregulator which interacted with the DNA-binding domain of members of the NR superfamily.

Expression

GT198 is selectively expressed in human testis, but in the mouse is present in the spleen and thymus in addition to the testis, with smaller amounts in the ovary.

PubMed

Phenotypes

Targeted deletion (knockout) of GT198 in mice suggests a crucial role in meiosis.

View GT198 Phenotypes section


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Nuclear Receptor Coactivator GT198 (GT198); Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

Primary References
Ko L, Cardona GR, Henrion-Caude A and Chin WW (2002) Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors. Mol Cell Biol 22, 357-69. View Abstract | View PubMed
Ijichi H, Tanaka T, Nakamura T, Yagi H, Hakuba A and Sato M (2000) Molecular cloning and characterization of a human homologue of TBPIP, a BRCA1 locus-related gene. Gene 248, 99-107. View Abstract | View PubMed

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