ARIP3

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Name
Androgen receptor-interacting protein 3
Symbol
ARIP3

Overview

ARIP3 is a testis specific zinc finger-containing protein originally characterized as a protein that interacted with Msx2, a homeobox gene product with a regulatory role in inductive tissue interactions. It was subsequently identified as nuclear receptor coregulator based on its role as a coactivator for the androgen receptor.

Expression

ARIP3 is expressed at low levels in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with a single major peak in the testis.

View full NURSA ARIP3 expression dataset

Phenotypes

Targeted disruption (knockout) of the ARIP3 gene results in reduced testis weight.

View ARIP3 Phenotypes section


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Androgen receptor-interacting protein-3 (ARIP3); Protein inhibitor of activated STAT proteins (PIASX); Msx-interacting-zincfinger (Miz1)

Primary References
Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL and Shuai K (2003) PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. J Biol Chem 278, 21327-30. View Abstract | View PubMed
Moilanen AM, Karvonen U, Poukka H, Yan W, Toppari J, Jänne OA and Palvimo JJ (1999) A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins. J Biol Chem 274, 3700-4. View Abstract | View PubMed
Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE and Maxson R (1997) Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA. Mech Dev 65, 3-17. View Abstract | View PubMed

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